Experimental autoimmune nigral damage in guinea pigs

Weidong Le; Joseph Engelhardt; Wen Jie Xie; Larry Schneider; R. Glenn Smith; Stanley H. Appel

doi:10.1016/0165-5728(94)00160-P

Experimental autoimmune nigral damage in guinea pigs

Weidong Le, Joseph Engelhardt, Wen Jie Xie, Larry Schneider, R. Glenn Smith, Stanley H. Appel

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33 Scopus citations

Abstract

An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.

Original language	English (US)
Pages (from-to)	45-53
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	57
Issue number	1-2
DOIs	https://doi.org/10.1016/0165-5728(94)00160-P
State	Published - Mar 1995

Keywords

Autoimmunity
Dopaminergic neurons
Parkinson's disease
Substantia nigra

ASJC Scopus subject areas

Neurology
Clinical Neurology
Immunology and Allergy
Immunology

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10.1016/0165-5728(94)00160-P

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title = "Experimental autoimmune nigral damage in guinea pigs",

abstract = "An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.",

keywords = "Autoimmunity, Dopaminergic neurons, Parkinson's disease, Substantia nigra",

author = "Weidong Le and Joseph Engelhardt and Xie, {Wen Jie} and Larry Schneider and Smith, {R. Glenn} and Appel, {Stanley H.}",

note = "Funding Information: We are grateful to Dr. Joseph Jankovic for his helpful review of the manuscript and to Dr. Jorge Aragon for his assistancew ith the statisticala nalysis. Supportedb y grantsf rom the Claude and Marie Ham-mill Foundation, the Temple Foundation, the OTKA (16061a, nd the ETT (T108/1990) Foundation of Hungary. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1995",

month = mar,

doi = "10.1016/0165-5728(94)00160-P",

language = "English (US)",

volume = "57",

pages = "45--53",

journal = "Journal of Neuroimmunology",

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T1 - Experimental autoimmune nigral damage in guinea pigs

AU - Le, Weidong

AU - Engelhardt, Joseph

AU - Xie, Wen Jie

AU - Schneider, Larry

AU - Smith, R. Glenn

AU - Appel, Stanley H.

N1 - Funding Information: We are grateful to Dr. Joseph Jankovic for his helpful review of the manuscript and to Dr. Jorge Aragon for his assistancew ith the statisticala nalysis. Supportedb y grantsf rom the Claude and Marie Ham-mill Foundation, the Temple Foundation, the OTKA (16061a, nd the ETT (T108/1990) Foundation of Hungary. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1995/3

Y1 - 1995/3

N2 - An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.

AB - An animal model of experimental autoimmune nigral damage (EAND) has been developed in guinea pigs by immunization with hybrid dopaminergic cells (MES 23.5). In such animals, loss of 40% of the substantia nigra (SN) neurons and damage to an additional 10% of SN neurons was associated with a 37-43% decrease of tyrosine hydroxylase (TH) activity and a 36% decrease of dopamine (DA) content in the nigral-striatum. Eight of the thirteen animals developed significant hypokinesia. The EAND model suggests that degeneration of dopaminergic neurons in SN can be caused by immune-mediated processes, which may help our understanding of the pathogenesis in Parkinson's disease.

KW - Autoimmunity

KW - Dopaminergic neurons

KW - Parkinson's disease

KW - Substantia nigra

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EP - 53

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Experimental autoimmune nigral damage in guinea pigs

Abstract

Keywords

ASJC Scopus subject areas

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