Experiences of liver retransplantation for postoperative diffuse biliary strictures

Yi Ma, Xiao Shun He, Xiao Feng Zhu, Dong Ping Wang, Guo Dong Wang, An Bin Hu, Wei Qiang Ju, Lin Wei Wu, Qiang Tai, Zhi Yong Guo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: To investigate the feasibility and management of retransplantation for diffuse biliary strictures occurring after initial liver transplantation. Methods: The clinical data of 53 consecutive liver retransplantation patients at our hospital from January 2001 to December 2009 were collected and analyzed retrospectively. Among them, 20 (37.7%) were due to diffuse biliary strictures. Results: Diffuse biliary strictures appeared at 3-16 months after initial transplantation. The mean time was 6.3 months. The specific types included intra-hepatic diffuse biliary strictures (n=16) and multi-strictures involving both intra- & extra-hepatic biliary ducts (n=4). Retransplantation was performed after a failure of intervention or/and other comprehensive treatments. Among them, 14 were cured and 6 died from peri-operative complications including serious abdominal infection & MODS (multiple organ dysfunction syndrome) (n=3, 50%), biliary fistula (n=2, 33.3%) and hepatic artery embolism (n=1, 16.7%). These patients were followed up for a mean time of 1.8 years (range: 1-5 years). The accumulative survival rates at 1, 3 and 6 months were 80.0%, 75.0% and 70.0% respectively. Conclusions: Liver retransplantation is the ultimate treatment for diffuse biliary strictures after liver transplantation. The survival rate is associated with operative timing, surgical techniques and peri-operative management.

Original languageEnglish (US)
Pages (from-to)1529-1532
Number of pages4
JournalNational Medical Journal of China
Issue number22
StatePublished - Jun 14 2011


  • Biliary strictures
  • Liver retransplantation
  • Liver transplantation
  • Postoperative complications

ASJC Scopus subject areas

  • Medicine(all)


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