Expansion of Candidate HPV-Specific T Cells in the Tumor Microenvironment during Chemoradiotherapy Is Prognostic in HPV16 Cancers

Lauren E. Colbert, Molly B. El Alam, Erica J. Lynn, Julianna Bronk, Tatiana V. Karpinets, Xiaogang Wu, Bhavana V. Chapman, Travis T. Sims, Daniel Lin, Ramez Kouzy, Julie Sammouri, Greyson Biegert, Andrea Y.Delgado Medrano, Adilene Olvera, K. Jagannadha Sastry, Patricia J. Eifel, Anuja Jhingran, Lilie Lin, Lois M. Ramondetta, Andrew P. FutrealAmir A. Jazaeri, Kathleen M. Schmeler, Jingyan Yue, Aparna Mitra, Kyoko Yoshida-Court, Jennifer A. Wargo, Travis N. Solley, Venkatesh Hegde, Sita S. Nookala, Ananta V. Yanamandra, Stephanie Dorta-Estremera, Geena Mathew, Rohit Kavukuntla, Cassidy Papso, Mustapha Ahmed-Kaddar, Minsoo Kim, Jianhua Zhang, Alexandre Reuben, Emma B. Holliday, Bruce D. Minsky, Albert C. Koong, Eugene J. Koay, Prajnan Das, Cullen M. Taniguchi, Ann Klopp

Research output: Contribution to journalArticlepeer-review

Abstract

Human papillomavirus (HPV) infection causes 600,000 new cancers worldwide each year. HPV-related cancers express the oncogenic proteins E6 and E7, which could serve as tumorspecific antigens. It is not known whether immunity to E6 and E7 evolves during chemoradiotherapy or affects survival. Using T cells from 2 HPV16 patients, we conducted functional T-cell assays to identify candidate HPV-specific T cells and common T-cell receptor motifs, which we then analyzed across 86 patients with HPV-related cancers. The HPV-specific clones and E7-related T-cell receptor motifs expanded in the tumor microenvironment over the course of treatment, whereas non-HPV-specific T cells did not. In HPV16 patients, improved recurrence-free survival was associated with HPV-responsive T-cell expansion during chemoradiotherapy.

Original languageEnglish (US)
Pages (from-to)259-271
Number of pages13
JournalCancer immunology research
Volume10
Issue number2
DOIs
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Immunology
  • Cancer Research

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