Exercising the worry away: How inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours

S. Moylan, H. A. Eyre, M. Maes, B. T. Baune, F. N. Jacka, M. Berk

Research output: Contribution to journalReview articlepeer-review

114 Scopus citations

Abstract

Regular physical activity exerts positive effects on anxiety disorder symptoms, although the biological mechanisms underpinning this effect are incompletely understood. Numerous lines of evidence support inflammation and oxidative and nitrogen stress (O&NS) as important in the pathogenesis of mood and anxiety disorders, and physical activity is known to influence these same pathways. This paper reviews the inter-relationships between anxiety disorders, physical activity and inflammation and O&NS, to explore whether modulation of inflammation and O&NS may in part underpin the positive effect of physical activity on anxiety disorders. Numerous studies support the notion that physical activity operates as an anti-inflammatory and anti-O&NS agent which potentially exerts positive effects on neuroplasticity, the expression of neurotrophins and normal neuronal functions. These effects may therefore influence the expression and evolution of anxiety disorders. Further exploration of this area may elicit a deeper understanding of the pathogenesis of anxiety disorders, and inform the development of integrated programmes including PA specifically suited to the treatment and prevention of anxiety disorders and symptoms.

Original languageEnglish (US)
Pages (from-to)573-584
Number of pages12
JournalNeuroscience and Biobehavioral Reviews
Volume37
Issue number4
DOIs
StatePublished - May 2013

Keywords

  • Anxiety disorders
  • Apoptosis
  • Exercise
  • Inflammation
  • Neuroplasticity
  • Neurotrophins
  • Oxidative stress
  • Physical activity
  • Prevention
  • Treatment

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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