Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities

Vincent C.T. Mok; Adrian Wong; Kelvin Wong; Winnie C.W. Chu; Yunyun Xiong; Anne Y.Y. Chan; Timothy C.Y. Kwok; Xintao Hu; W. K. Lee; Wai Kwong Tang; Ka Sing Lawrence Wong; Stephen Wong

doi:10.1159/000318744

Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities

Vincent C.T. Mok, Adrian Wong, Kelvin Wong, Winnie C.W. Chu, Yunyun Xiong, Anne Y.Y. Chan, Timothy C.Y. Kwok, Xintao Hu, W. K. Lee, Wai Kwong Tang, Ka Sing Lawrence Wong, Stephen Wong

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Background/Aims: This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH). Methods: The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms. Results: Seventy-seven stroke patients (mean WMH volume: 39.5 cm³) were recruited. Thirty patients (39%) had ≥1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression. Conclusion: Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.

Original language	English (US)
Pages (from-to)	254-260
Number of pages	7
Journal	Dementia and Geriatric Cognitive Disorders
Volume	30
Issue number	3
DOIs	https://doi.org/10.1159/000318744
State	Published - Oct 2010

Keywords

Depression
Executive function
Frontal lobe atrophy
Neuropsychiatry
Stroke
White matter hyperintensities

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Cognitive Neuroscience

Divisions

Medical Oncology

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10.1159/000318744

Cite this

Mok, V. C. T., Wong, A., Wong, K., Chu, W. C. W., Xiong, Y., Chan, A. Y. Y., Kwok, T. C. Y., Hu, X., Lee, W. K., Tang, W. K., Wong, K. S. L., & Wong, S. (2010). Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities. Dementia and Geriatric Cognitive Disorders, 30(3), 254-260. https://doi.org/10.1159/000318744

Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities. / Mok, Vincent C.T.; Wong, Adrian; Wong, Kelvin et al.
In: Dementia and Geriatric Cognitive Disorders, Vol. 30, No. 3, 10.2010, p. 254-260.

Research output: Contribution to journal › Article › peer-review

Mok, VCT, Wong, A, Wong, K, Chu, WCW, Xiong, Y, Chan, AYY, Kwok, TCY, Hu, X, Lee, WK, Tang, WK, Wong, KSL & Wong, S 2010, 'Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities', Dementia and Geriatric Cognitive Disorders, vol. 30, no. 3, pp. 254-260. https://doi.org/10.1159/000318744

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abstract = "Background/Aims: This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH). Methods: The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms. Results: Seventy-seven stroke patients (mean WMH volume: 39.5 cm3) were recruited. Thirty patients (39\%) had ≥1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression. Conclusion: Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.",

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AU - Xiong, Yunyun

AU - Chan, Anne Y.Y.

AU - Kwok, Timothy C.Y.

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AU - Tang, Wai Kwong

AU - Wong, Ka Sing Lawrence

AU - Wong, Stephen

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Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities

Abstract

Keywords

ASJC Scopus subject areas

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