Executive dysfunction and left frontal white matter hyperintensities are correlated with neuropsychiatric symptoms in stroke patients with confluent white matter hyperintensities

Vincent C.T. Mok, Adrian Wong, Kelvin Wong, Winnie C.W. Chu, Yunyun Xiong, Anne Y.Y. Chan, Timothy C.Y. Kwok, Xintao Hu, W. K. Lee, Wai Kwong Tang, Ka Sing Lawrence Wong, Stephen Wong

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background/Aims: This study aimed to determine the clinical and neuroimaging correlates of the presence of neuropsychiatric symptoms in stroke patients with age-related confluent white matter hyperintensities (WMH). Methods: The Neuropsychiatric Inventory was utilized to detect the presence of 12 symptoms. Multivariate logistic regression models were used to identify clinical and neuroimaging correlates of the presence of symptoms. Results: Seventy-seven stroke patients (mean WMH volume: 39.5 cm3) were recruited. Thirty patients (39%) had ≥1 neuropsychiatric symptom. Poor executive function was associated with the presence of any symptoms and symptoms other than depression. More severe left frontal WMH was associated with depression. Conclusion: Executive dysfunction and left frontal WMH are correlated with neuropsychiatric symptoms in these patients.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume30
Issue number3
DOIs
StatePublished - Oct 2010

Keywords

  • Depression
  • Executive function
  • Frontal lobe atrophy
  • Neuropsychiatry
  • Stroke
  • White matter hyperintensities

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience

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