Excretion of Steroid Hormones in Adults: Steroids in Faeces from Adults

Håkan Eriksson, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The steroids in faeces from three healthy persons, one woman and two men, were analyzed by gas‐liquid chromatography and gas chromatography‐mass spectrometry. Both C19O2, C19O3, C21O2 and C21O3 steroids were found in the free steroid and in the steroid monosulphate fractions. Incubation of various precursor steroids with intestinal contents recovered from the ileostoma of a colectomized patient demonstrated the presence of intestinal bacterial 16α‐ and 21‐dehydroxylating enzymes. Furthermore, it was shown that a Δ16‐C21 steroid was converted to a 17α‐pregnane derivative and that the side chain of 11β,21‐dihydroxy‐4‐pregnene‐3,20‐dione could be removed by the intestinal bacteria.

Original languageEnglish (US)
Pages (from-to)146-150
Number of pages5
JournalEuropean Journal of Biochemistry
Volume18
Issue number1
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • Biochemistry

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