Excretion and anticonvulsant activity of steroid hormones in an infant with infantile spasm and hypsarrhytmia treated with excessive doses of ACTH

Peter Eneroth, Jan-Ake Gustafsson, Harry Ferngren, Bo Hellström

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The excretion of steroids in urine and faeces was studied in an infant with infantile spasm with hypsarrhytmia. The analyses, which were carried out by gas-liquid chromatography and gas chromatography-mass spectrometry, were done before and after the infant was treated with excessive doses of ACTH. Prior to treatment the infant excreted less than 0.1 mg/24 h of individual steroids but after treatment the concentration in urine and faeces of several steroids increased 20-30 fold and the total excretion was about 12 mg/24 h both in urine and faeces. All the quantitatively predominant steroids excreted after ACTH treatment had a 3β-hydroxy-5-ene-structure: 3β,16α-dihydroxy-5-androsten-17-one, 3β,17β-dihydroxy-5-androsten-16-one, 5-pregnene-3β,20α-diol, 3β,16α-dihydroxy-5-pregnen-20-one, 3ξ,20ξ-dihydroxy-5-pregnen-16-one and 5-pregnene-3β,17α,20α-triol. 5-Pregnene-3β,20α-diol had an anticonvulsant activity when tested on newborn mice and the hypothesis is presented that the antiepileptic effects of ACTH in infants with hypsarrhytmia may be mediated via 3β-hydroxy-5-ene-steroids.

Original languageEnglish (US)
Pages (from-to)877-887
Number of pages11
JournalJournal of Steroid Biochemistry
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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