Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Jian You, Guodong Zhang, Chun Li

Research output: Contribution to journalArticle

466 Scopus citations

Abstract

We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

Original languageEnglish (US)
Pages (from-to)1033-1041
Number of pages9
JournalACS Nano
Volume4
Issue number2
DOIs
StatePublished - Feb 23 2010

Keywords

  • Doxorubicin
  • Hollow gold nanospheres
  • Nearinfrared light. antitumor activity
  • Triggered release

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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