Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Jian You; Guodong Zhang; Chun Li

doi:10.1021/nn901181c

Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Jian You, Guodong Zhang, Chun Li

Academic Institute

Research output: Contribution to journal › Article › peer-review

538 Scopus citations

Abstract

We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

Original language	English (US)
Pages (from-to)	1033-1041
Number of pages	9
Journal	ACS Nano
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/nn901181c
State	Published - Feb 23 2010

Keywords

Doxorubicin
Hollow gold nanospheres
Nearinfrared light. antitumor activity
Triggered release

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

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10.1021/nn901181c

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title = "Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release",

abstract = "We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.",

keywords = "Doxorubicin, Hollow gold nanospheres, Nearinfrared light. antitumor activity, Triggered release",

author = "Jian You and Guodong Zhang and Chun Li",

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AU - You, Jian

AU - Zhang, Guodong

AU - Li, Chun

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Y1 - 2010/2/23

N2 - We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

AB - We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH. Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.

KW - Doxorubicin

KW - Hollow gold nanospheres

KW - Nearinfrared light. antitumor activity

KW - Triggered release

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Exceptionally high payload of doxorubicin in hollow gold nanospheres for near-infrared light-triggered drug release

Abstract

Keywords

ASJC Scopus subject areas

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