Exaptation of retroviral syncytin for development of syncytialized placenta, its limited homology to the sars-cov-2 spike protein and arguments against disturbing narrative in the context of covid-19 vaccination

Malgorzata Kloc, Ahmed Uosef, Jacek Z. Kubiak, Rafik M. Ghobrial

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Human placenta formation relies on the interaction between fused trophoblast cells of the embryo with uterine endometrium. The fusion between trophoblast cells, first into cytotrophoblast and then into syncytiotrophoblast, is facilitated by the fusogenic protein syncytin. Syncytin derives from an envelope glycoprotein (ENV) of retroviral origin. In exogenous retroviruses, the envelope glycoproteins coded by env genes allow fusion of the viral envelope with the host cell membrane and entry of the virus into a host cell. During mammalian evolution, the env genes have been repeatedly, and independently, captured by various mammalian species to facilitate the formation of the placenta. Such a shift in the function of a gene, or a trait, for a different purpose during evolution is called an exaptation (co-option). We discuss the structure and origin of the placenta, the fusogenic and non-fusogenic functions of syncytin, and the mechanism of cell fusion. We also comment on an alleged danger of the COVID-19 vaccine based on the presupposed similarity between syncytin and the SARS-CoV-2 spike protein.

Original languageEnglish (US)
Article number238
JournalBiology
Volume10
Issue number3
DOIs
StatePublished - Mar 19 2021

Keywords

  • COVID-19 vaccine
  • Placenta
  • Retrovirus
  • SARS-CoV-2
  • Spike protein
  • Syncytin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

COVID-19 Keywords (backend)

  • SARS-CoV-2
  • COVID-19

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