Abstract
Background-Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study-To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods-We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results-No mutation in the MSX1 gene was identified in our cohort. Conclusions-Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.
Original language | English (US) |
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Pages (from-to) | 442-444 |
Number of pages | 3 |
Journal | Acta Neurologica Scandinavica |
Volume | 120 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2009 |
Keywords
- Coding region
- Muscle segment homeobox drosophila homolog of 1 gene
- Mutation
- Parkinson's disease
- Transcription factor
ASJC Scopus subject areas
- Clinical Neurology
- Neurology