Examination of the MSX1 gene in patients with Parkinson's disease

H. Deng; S. H. Zhu; W. D. Le; H. R. Yang; H. W. Lv; H. B. Xu; W. J. Xie; J. Jankovic

doi:10.1111/j.1600-0404.2009.01271.x

Examination of the MSX1 gene in patients with Parkinson's disease

H. Deng, S. H. Zhu, W. D. Le, H. R. Yang, H. W. Lv, H. B. Xu, W. J. Xie, J. Jankovic

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

Background-Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study-To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods-We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results-No mutation in the MSX1 gene was identified in our cohort. Conclusions-Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.

Original language	English (US)
Pages (from-to)	442-444
Number of pages	3
Journal	Acta Neurologica Scandinavica
Volume	120
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0404.2009.01271.x
State	Published - Dec 2009

Keywords

Coding region
Muscle segment homeobox drosophila homolog of 1 gene
Mutation
Parkinson's disease
Transcription factor

ASJC Scopus subject areas

Clinical Neurology
Neurology

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title = "Examination of the MSX1 gene in patients with Parkinson's disease",

abstract = "Background-Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study-To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods-We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results-No mutation in the MSX1 gene was identified in our cohort. Conclusions-Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.",

keywords = "Coding region, Muscle segment homeobox drosophila homolog of 1 gene, Mutation, Parkinson's disease, Transcription factor",

author = "H. Deng and Zhu, {S. H.} and Le, {W. D.} and Yang, {H. R.} and Lv, {H. W.} and Xu, {H. B.} and Xie, {W. J.} and J. Jankovic",

year = "2009",

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AU - Deng, H.

AU - Zhu, S. H.

AU - Le, W. D.

AU - Yang, H. R.

AU - Lv, H. W.

AU - Xu, H. B.

AU - Xie, W. J.

AU - Jankovic, J.

PY - 2009/12

Y1 - 2009/12

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AB - Background-Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study-To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods-We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results-No mutation in the MSX1 gene was identified in our cohort. Conclusions-Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.

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KW - Muscle segment homeobox drosophila homolog of 1 gene

KW - Mutation

KW - Parkinson's disease

KW - Transcription factor

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