Examination of the MSX1 gene in patients with Parkinson's disease

H. Deng, S. H. Zhu, W. D. Le, H. R. Yang, H. W. Lv, H. B. Xu, W. J. Xie, J. Jankovic

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background-Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study-To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods-We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing. Results-No mutation in the MSX1 gene was identified in our cohort. Conclusions-Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.

Original languageEnglish (US)
Pages (from-to)442-444
Number of pages3
JournalActa Neurologica Scandinavica
Volume120
Issue number6
DOIs
StatePublished - Dec 2009

Keywords

  • Coding region
  • Muscle segment homeobox drosophila homolog of 1 gene
  • Mutation
  • Parkinson's disease
  • Transcription factor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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