Examination of the MASH1 gene in patients with Parkinson's disease

Hao Deng; Huarong Yang; Weidong Le; Xiong Deng; Hongbo Xu; Wei Xiong; Shaihong Zhu; Wenjie Xie; Zhi Song; Joseph Jankovic

doi:10.1016/j.bbrc.2010.01.061

Examination of the MASH1 gene in patients with Parkinson's disease

Hao Deng, Huarong Yang, Weidong Le, Xiong Deng, Hongbo Xu, Wei Xiong, Shaihong Zhu, Wenjie Xie, Zhi Song, Joseph Jankovic

Houston Methodist

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding region of the MASH1 gene plays a role in the etiology of PD Caucasian patients, we analyzed the whole coding region of the MASH1 gene in PD patients from North America. Case-control analysis showed nominal association between polyglutamine length variation in MASH1 and Caucasian PD, 8% of PD vs 13% of normal controls had 13 CAG repeats (p = 0.027, χ² = 4.906). Our data support the role of the polyglutamine length variants in the MASH1 gene in PD susceptibility.

Original language	English (US)
Pages (from-to)	548-550
Number of pages	3
Journal	Biochemical and Biophysical Research Communications
Volume	392
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2010.01.061
State	Published - Feb 19 2010

Keywords

Parkinson's disease
Polyglutamine length variant
The mammalian achaete-scute homolog 1 gene

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Molecular Biology

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10.1016/j.bbrc.2010.01.061

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@article{44e2f26b60494147b138c9a2723b269d,

title = "Examination of the MASH1 gene in patients with Parkinson's disease",

abstract = "Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding region of the MASH1 gene plays a role in the etiology of PD Caucasian patients, we analyzed the whole coding region of the MASH1 gene in PD patients from North America. Case-control analysis showed nominal association between polyglutamine length variation in MASH1 and Caucasian PD, 8\% of PD vs 13\% of normal controls had 13 CAG repeats (p = 0.027, χ2 = 4.906). Our data support the role of the polyglutamine length variants in the MASH1 gene in PD susceptibility.",

keywords = "Parkinson's disease, Polyglutamine length variant, The mammalian achaete-scute homolog 1 gene",

author = "Hao Deng and Huarong Yang and Weidong Le and Xiong Deng and Hongbo Xu and Wei Xiong and Shaihong Zhu and Wenjie Xie and Zhi Song and Joseph Jankovic",

note = "Funding Information: This study was supported by the Fund of Hunan Province for Distinguished Young Scholar (09JJ1005), Sheng Hua Scholars Program and Outstanding Youth Foundation of Central South University, China (H.D.), National Natural Science Foundation of China (30871351, 30971534), Program for New Century Excellent Talents in University of Ministry of Education of PR China (NCET-080563), the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (H.D.), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, the Diana Helis Henry Medical Research Foundation (W.L.) and the National Parkinson Foundation to the Baylor College of Medicine Center of Excellence (J.J.). The authors thank the participating patients and the investigators at the Parkinson{\textquoteright}s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, for their cooperation and their efforts in collecting the genetic information and DNA specimens.",

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language = "English (US)",

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AU - Deng, Hao

AU - Yang, Huarong

AU - Le, Weidong

AU - Deng, Xiong

AU - Xu, Hongbo

AU - Xiong, Wei

AU - Zhu, Shaihong

AU - Xie, Wenjie

AU - Song, Zhi

AU - Jankovic, Joseph

N1 - Funding Information: This study was supported by the Fund of Hunan Province for Distinguished Young Scholar (09JJ1005), Sheng Hua Scholars Program and Outstanding Youth Foundation of Central South University, China (H.D.), National Natural Science Foundation of China (30871351, 30971534), Program for New Century Excellent Talents in University of Ministry of Education of PR China (NCET-080563), the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (H.D.), Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province, the Diana Helis Henry Medical Research Foundation (W.L.) and the National Parkinson Foundation to the Baylor College of Medicine Center of Excellence (J.J.). The authors thank the participating patients and the investigators at the Parkinson’s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, for their cooperation and their efforts in collecting the genetic information and DNA specimens.

PY - 2010/2/19

Y1 - 2010/2/19

N2 - Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding region of the MASH1 gene plays a role in the etiology of PD Caucasian patients, we analyzed the whole coding region of the MASH1 gene in PD patients from North America. Case-control analysis showed nominal association between polyglutamine length variation in MASH1 and Caucasian PD, 8% of PD vs 13% of normal controls had 13 CAG repeats (p = 0.027, χ2 = 4.906). Our data support the role of the polyglutamine length variants in the MASH1 gene in PD susceptibility.

AB - Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding region of the MASH1 gene plays a role in the etiology of PD Caucasian patients, we analyzed the whole coding region of the MASH1 gene in PD patients from North America. Case-control analysis showed nominal association between polyglutamine length variation in MASH1 and Caucasian PD, 8% of PD vs 13% of normal controls had 13 CAG repeats (p = 0.027, χ2 = 4.906). Our data support the role of the polyglutamine length variants in the MASH1 gene in PD susceptibility.

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Examination of the MASH1 gene in patients with Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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