Examination of the MASH1 gene in patients with Parkinson's disease

Hao Deng, Huarong Yang, Weidong Le, Xiong Deng, Hongbo Xu, Wei Xiong, Shaihong Zhu, Wenjie Xie, Zhi Song, Joseph Jankovic

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The mammalian achaete-scute homolog 1 gene (MASH1) controls development of the locus coeruleus. Furthermore, polyglutamine length variation in MASH1 gene appears to confer protective effects against PD, at least in Japanese population. To determine whether genetic variation in the coding region of the MASH1 gene plays a role in the etiology of PD Caucasian patients, we analyzed the whole coding region of the MASH1 gene in PD patients from North America. Case-control analysis showed nominal association between polyglutamine length variation in MASH1 and Caucasian PD, 8% of PD vs 13% of normal controls had 13 CAG repeats (p = 0.027, χ2 = 4.906). Our data support the role of the polyglutamine length variants in the MASH1 gene in PD susceptibility.

Original languageEnglish (US)
Pages (from-to)548-550
Number of pages3
JournalBiochemical and Biophysical Research Communications
Volume392
Issue number4
DOIs
StatePublished - Feb 19 2010

Keywords

  • Parkinson's disease
  • Polyglutamine length variant
  • The mammalian achaete-scute homolog 1 gene

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

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