Evolution of the regulators of G-protein signaling multigene family in mouse and human

David A. Sierra, Debra J. Gilbert, Deborah Householder, Nick V. Grishin, Kan Yu, Pallavi Ukidwe, Sheryll A. Barker, Wei He, Theodore G. Wensel, Glen Otero, Greg Brown, Neal G. Copeland, Nancy A. Jenkins, Thomas M. Wilkie

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


The regulators of G-protein signaling (RGS) proteins are important regulatory and structural components of G-protein coupled receptor complexes. RGS proteins are GTPase activating proteins (GAPs) of Gi- and Gq-class Gα proteins, and thereby accelerate signaling kinetics and termination. Here, we mapped the chromosomal positions of all 21 Rgs genes in mouse, and determined human RGS gene structures using genomic sequence from partially assembled bacterial artificial chromosomes (BACs) and Celera fragments. In mice and humans, 18 of 21 RGS genes are either tandemly duplicated or tightly linked to genes encoding other components of G-protein signaling pathways, including Gα, Gγ, receptors (GPCR), and receptor kinases (GPRK). A phylogenetic tree revealed seven RGS gene subfamilies in the yeast and metazoan genomes that have been sequenced. We propose that similar systematic analyses of all multigene families from human and other mammalian genomes will help complete the assembly and annotation of the human genome sequence.

Original languageEnglish (US)
Pages (from-to)177-185
Number of pages9
Issue number2
StatePublished - Feb 2002


  • Gγ-like (GGL)
  • G-protein coupled receptor (GPCR)
  • GAP
  • GTPase accelerating protein (GAP)
  • Multigene family
  • Phylogenetic tree

ASJC Scopus subject areas

  • Genetics


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