TY - JOUR
T1 - Evidence of altered metabolism of cellular membranes in bipolar disorder comorbid with post-traumatic stress disorder
AU - Jabbari-zadeh, Faramarz
AU - Cao, Bo
AU - Stanley, Jeffrey A.
AU - Liu, Yang
AU - Wu, Mon Ju
AU - Tannous, Jonika
AU - Lopez, Mizuki
AU - Sanches, Marsal
AU - Mwangi, Benson
AU - Zunta-Soares, Giovana B.
AU - Soares, Jair C.
N1 - Funding Information:
Supported in part by NIMH grant R01 085667, the Dunn Research Foundation, and the Pat Rutherford, Jr. Endowed Chair in Psychiatry (Jair C. Soares) and NARSAD Young Investigator Grants of The Brain & Behavior Research Foundation (Bo Cao). Mr. Jabbari-zadeh1was supported by the Alberta Innovates Summer Research Studentship. Drs. Cao, Stanley, Passos, Mwangi, Selvaraj, and Zunta-Soares reported no biomedical financial interests or potential conflicts of interest. Dr. Soares has received grants/research support from Forrest, BMS, J&J, Merck, Stanley Medical Research Institute, and has been a speaker for Pfizer and Abbott.
Funding Information:
Supported in part by NIMH grant R01 085667, the Dunn Research Foundation, and the Pat Rutherford, Jr. Endowed Chair in Psychiatry (Jair C. Soares) and NARSAD Young Investigator Grants of The Brain & Behavior Research Foundation (Bo Cao). Mr. Jabbari-zadeh1was supported by the Alberta Innovates Summer Research Studentship. Drs. Cao, Stanley, Passos, Mwangi, Selvaraj, and Zunta-Soares reported no biomedical financial interests or potential conflicts of interest. Dr. Soares has received grants/research support from Forrest, BMS, J&J, Merck, Stanley Medical Research Institute, and has been a speaker for Pfizer and Abbott.
Publisher Copyright:
© 2021
PY - 2021/6/15
Y1 - 2021/6/15
N2 - In proton magnetic resonance spectroscopy (¹H MRS) studies, aberrant levels of choline-containing compounds that include glycerophosphocholine plus phosphocholine (GPC+PC), can signify alterations in the metabolism of cellular membrane phospholipids (MPLs) from a healthy baseline. In a recent ¹H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I). Post-traumatic stress disorder (PTSD) can worsen the severity of BP-I, but it is unclear whether the effect of a PTSD comorbidity in BP-I is associated with altered MPL metabolism. The purpose of this study was to re-investigate the ¹H MRS data to determine whether the regional extent of elevated GPC+PC was greater in BP-I patients with PTSD (BP-I/wPTSD) compared to BP-I without comorbid PTSD (BP-I/woPTSD) patients and healthy controls. GPC+PC levels from four brain areas [the anterior cingulate cortex (ACC), anterior-dorsal ACC, caudate, and putamen] were measured in 14 BP-I/wPTSD, 36 BP-I/woPTSD, and 44 healthy controls using a multi-voxel 1H MRS approach on a 3 Tesla system with high spatial resolution and absolute quantification. Results show a significant increase in GPC+PC levels from the caudate and putamen of BP-I/wPTSD patients compared to healthy controls (P<0.05) and in the putamen compared to BP-I/woPTSD patients (P<0.05). These findings are consistent with evidence of elevated degradation of MPLs in the neuropil that is more pronounced in BP-I patients with comorbid PTSD.
AB - In proton magnetic resonance spectroscopy (¹H MRS) studies, aberrant levels of choline-containing compounds that include glycerophosphocholine plus phosphocholine (GPC+PC), can signify alterations in the metabolism of cellular membrane phospholipids (MPLs) from a healthy baseline. In a recent ¹H MRS study, we reported increased GPC+PC in cortical and subcortical areas of adult patients with bipolar disorder I (BP-I). Post-traumatic stress disorder (PTSD) can worsen the severity of BP-I, but it is unclear whether the effect of a PTSD comorbidity in BP-I is associated with altered MPL metabolism. The purpose of this study was to re-investigate the ¹H MRS data to determine whether the regional extent of elevated GPC+PC was greater in BP-I patients with PTSD (BP-I/wPTSD) compared to BP-I without comorbid PTSD (BP-I/woPTSD) patients and healthy controls. GPC+PC levels from four brain areas [the anterior cingulate cortex (ACC), anterior-dorsal ACC, caudate, and putamen] were measured in 14 BP-I/wPTSD, 36 BP-I/woPTSD, and 44 healthy controls using a multi-voxel 1H MRS approach on a 3 Tesla system with high spatial resolution and absolute quantification. Results show a significant increase in GPC+PC levels from the caudate and putamen of BP-I/wPTSD patients compared to healthy controls (P<0.05) and in the putamen compared to BP-I/woPTSD patients (P<0.05). These findings are consistent with evidence of elevated degradation of MPLs in the neuropil that is more pronounced in BP-I patients with comorbid PTSD.
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U2 - 10.1016/j.jad.2021.04.011
DO - 10.1016/j.jad.2021.04.011
M3 - Article
C2 - 33951550
AN - SCOPUS:85105014716
VL - 289
SP - 81
EP - 87
JO - J Affect Disord
JF - J Affect Disord
SN - 0165-0327
ER -