Phosphate secretion in the rat kidney was examined utilizing direct capillary microinjections of a solution containing radioactive phosphate and inulin. The 32P/3H urine/perfusion solution ratio of counts at the urinary arrival time of inulin was 0.24±0.02 in the microinjected left kidney compared to 0.18±0.01 in the right kidney (p<0.05). The difference between the ratio of counts in the two kidneys was not influenced by cyanide. PTH infusion, however, increased the differences in recoveries between the two kidneys. These studies indicate that passive phosphate entry from peritubular capillary blood into the tubular lumen does occur in the rat kidney and can be increased by the administration of PTH.
|Original language||English (US)|
|Number of pages||7|
|Journal||Mineral and Electrolyte Metabolism|
|State||Published - Jan 1 1978|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism