Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study

Research output: Contribution to journalArticle

Adam Domonkos Tarnoki, Claudio Baracchini, David Laszlo Tarnoki, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Andrea Agnes Molnar, Giorgio Meneghetti, Maria Antonietta Stazi, Emanuela Medda, Rodolfo Cotichini, Lorenza Nisticò, Corrado Fagnani, Janos Osztovits, Gyorgy Jermendy, Istvan Preda, Robert Gabor Kiss, Julia Metneki, Tamas Horvath & 7 others Giacomo Pucci, Pal Bata, Kinga Karlinger, Levente Littvay, Viktor Berczi, Zsolt Garami, Giuseppe Schillaci

Background and Purpose: Few family studies reported moderate genetic impact on the presence and scores of carotid plaques. However, the heritability of carotid plaque characteristics remains still unclear. Twin studies more reliably estimate the relative contribution of genes to these traits in contrast to family study design. Methods: One hundred ninety-two monozygotic and 83 dizygotic adult twin pairs (age 49 ± 15 years) from Italy, Hungary, and the United States underwent B-mode and color Doppler ultrasound of bilateral common, internal, and external carotid arteries. Results: Age-, sex-, and country-adjusted heritability was 78% for the presence of carotid plaque (95% CI, 55%-90%), 74% for plaque echogenicity (hypoechoic, hyperechoic, or mixed; 95% CI, 38%-87%), 69% for plaque size (area in mm2 in longitudinal plane; < or >50 percentile; 95% CI, 16%-86%), 74% for plaque sidedness (unilateral or bilateral; 95% CI, 25%-90%), 74% for plaque numerosity (95% CI, 26%-86%), 68% (95% CI, 40%-84%), and 66% (95% CI, 32%-90%) for the presence of plaque in carotid bulbs and proximal internal carotid arteries. No role of shared environmental factors was found. Unique environmental factors were responsible for the remaining variance (22%-34%). Controlling for relevant covariates did not change the results significantly. Conclusions: The heritability of ultrasound characteristics of carotid plaque is high. Unshared environmental effects account for a modest portion of the variance. Our findings should stimulate the search for genes responsible for these traits.

Original languageEnglish
Pages (from-to)3168-3172
Number of pages5
JournalStroke
Volume43
Issue number12
DOIs
StatePublished - Dec 1 2012

PMID: 23086674

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Evidence for a strong genetic influence on carotid plaque characteristics : An International twin study. / Tarnoki, Adam Domonkos; Baracchini, Claudio; Tarnoki, David Laszlo; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Molnar, Andrea Agnes; Meneghetti, Giorgio; Stazi, Maria Antonietta; Medda, Emanuela; Cotichini, Rodolfo; Nisticò, Lorenza; Fagnani, Corrado; Osztovits, Janos; Jermendy, Gyorgy; Preda, Istvan; Kiss, Robert Gabor; Metneki, Julia; Horvath, Tamas; Pucci, Giacomo; Bata, Pal; Karlinger, Kinga; Littvay, Levente; Berczi, Viktor; Garami, Zsolt; Schillaci, Giuseppe.

In: Stroke, Vol. 43, No. 12, 01.12.2012, p. 3168-3172.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Baracchini, C, Tarnoki, DL, Lucatelli, P, Boatta, E, Zini, C, Fanelli, F, Molnar, AA, Meneghetti, G, Stazi, MA, Medda, E, Cotichini, R, Nisticò, L, Fagnani, C, Osztovits, J, Jermendy, G, Preda, I, Kiss, RG, Metneki, J, Horvath, T, Pucci, G, Bata, P, Karlinger, K, Littvay, L, Berczi, V, Garami, Z & Schillaci, G 2012, 'Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study' Stroke, vol. 43, no. 12, pp. 3168-3172. https://doi.org/10.1161/STROKEAHA.112.666016

APA

Tarnoki, A. D., Baracchini, C., Tarnoki, D. L., Lucatelli, P., Boatta, E., Zini, C., ... Schillaci, G. (2012). Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study. Stroke, 43(12), 3168-3172. https://doi.org/10.1161/STROKEAHA.112.666016

Vancouver

Tarnoki AD, Baracchini C, Tarnoki DL, Lucatelli P, Boatta E, Zini C et al. Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study. Stroke. 2012 Dec 1;43(12):3168-3172. https://doi.org/10.1161/STROKEAHA.112.666016

Author

Tarnoki, Adam Domonkos ; Baracchini, Claudio ; Tarnoki, David Laszlo ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Fanelli, Fabrizio ; Molnar, Andrea Agnes ; Meneghetti, Giorgio ; Stazi, Maria Antonietta ; Medda, Emanuela ; Cotichini, Rodolfo ; Nisticò, Lorenza ; Fagnani, Corrado ; Osztovits, Janos ; Jermendy, Gyorgy ; Preda, Istvan ; Kiss, Robert Gabor ; Metneki, Julia ; Horvath, Tamas ; Pucci, Giacomo ; Bata, Pal ; Karlinger, Kinga ; Littvay, Levente ; Berczi, Viktor ; Garami, Zsolt ; Schillaci, Giuseppe. / Evidence for a strong genetic influence on carotid plaque characteristics : An International twin study. In: Stroke. 2012 ; Vol. 43, No. 12. pp. 3168-3172.

BibTeX

@article{41943a790220455f90298ee90578d0ea,
title = "Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study",
abstract = "Background and Purpose: Few family studies reported moderate genetic impact on the presence and scores of carotid plaques. However, the heritability of carotid plaque characteristics remains still unclear. Twin studies more reliably estimate the relative contribution of genes to these traits in contrast to family study design. Methods: One hundred ninety-two monozygotic and 83 dizygotic adult twin pairs (age 49 ± 15 years) from Italy, Hungary, and the United States underwent B-mode and color Doppler ultrasound of bilateral common, internal, and external carotid arteries. Results: Age-, sex-, and country-adjusted heritability was 78{\%} for the presence of carotid plaque (95{\%} CI, 55{\%}-90{\%}), 74{\%} for plaque echogenicity (hypoechoic, hyperechoic, or mixed; 95{\%} CI, 38{\%}-87{\%}), 69{\%} for plaque size (area in mm2 in longitudinal plane; < or >50 percentile; 95{\%} CI, 16{\%}-86{\%}), 74{\%} for plaque sidedness (unilateral or bilateral; 95{\%} CI, 25{\%}-90{\%}), 74{\%} for plaque numerosity (95{\%} CI, 26{\%}-86{\%}), 68{\%} (95{\%} CI, 40{\%}-84{\%}), and 66{\%} (95{\%} CI, 32{\%}-90{\%}) for the presence of plaque in carotid bulbs and proximal internal carotid arteries. No role of shared environmental factors was found. Unique environmental factors were responsible for the remaining variance (22{\%}-34{\%}). Controlling for relevant covariates did not change the results significantly. Conclusions: The heritability of ultrasound characteristics of carotid plaque is high. Unshared environmental effects account for a modest portion of the variance. Our findings should stimulate the search for genes responsible for these traits.",
author = "Tarnoki, {Adam Domonkos} and Claudio Baracchini and Tarnoki, {David Laszlo} and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Fabrizio Fanelli and Molnar, {Andrea Agnes} and Giorgio Meneghetti and Stazi, {Maria Antonietta} and Emanuela Medda and Rodolfo Cotichini and Lorenza Nistic{\`o} and Corrado Fagnani and Janos Osztovits and Gyorgy Jermendy and Istvan Preda and Kiss, {Robert Gabor} and Julia Metneki and Tamas Horvath and Giacomo Pucci and Pal Bata and Kinga Karlinger and Levente Littvay and Viktor Berczi and Zsolt Garami and Giuseppe Schillaci",
year = "2012",
month = "12",
day = "1",
doi = "10.1161/STROKEAHA.112.666016",
language = "English",
volume = "43",
pages = "3168--3172",
journal = "Stroke",
issn = "0039-2499",
number = "12",

}

RIS

TY - JOUR

T1 - Evidence for a strong genetic influence on carotid plaque characteristics

T2 - Stroke

AU - Tarnoki, Adam Domonkos

AU - Baracchini, Claudio

AU - Tarnoki, David Laszlo

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Fanelli, Fabrizio

AU - Molnar, Andrea Agnes

AU - Meneghetti, Giorgio

AU - Stazi, Maria Antonietta

AU - Medda, Emanuela

AU - Cotichini, Rodolfo

AU - Nisticò, Lorenza

AU - Fagnani, Corrado

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Preda, Istvan

AU - Kiss, Robert Gabor

AU - Metneki, Julia

AU - Horvath, Tamas

AU - Pucci, Giacomo

AU - Bata, Pal

AU - Karlinger, Kinga

AU - Littvay, Levente

AU - Berczi, Viktor

AU - Garami, Zsolt

AU - Schillaci, Giuseppe

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Background and Purpose: Few family studies reported moderate genetic impact on the presence and scores of carotid plaques. However, the heritability of carotid plaque characteristics remains still unclear. Twin studies more reliably estimate the relative contribution of genes to these traits in contrast to family study design. Methods: One hundred ninety-two monozygotic and 83 dizygotic adult twin pairs (age 49 ± 15 years) from Italy, Hungary, and the United States underwent B-mode and color Doppler ultrasound of bilateral common, internal, and external carotid arteries. Results: Age-, sex-, and country-adjusted heritability was 78% for the presence of carotid plaque (95% CI, 55%-90%), 74% for plaque echogenicity (hypoechoic, hyperechoic, or mixed; 95% CI, 38%-87%), 69% for plaque size (area in mm2 in longitudinal plane; < or >50 percentile; 95% CI, 16%-86%), 74% for plaque sidedness (unilateral or bilateral; 95% CI, 25%-90%), 74% for plaque numerosity (95% CI, 26%-86%), 68% (95% CI, 40%-84%), and 66% (95% CI, 32%-90%) for the presence of plaque in carotid bulbs and proximal internal carotid arteries. No role of shared environmental factors was found. Unique environmental factors were responsible for the remaining variance (22%-34%). Controlling for relevant covariates did not change the results significantly. Conclusions: The heritability of ultrasound characteristics of carotid plaque is high. Unshared environmental effects account for a modest portion of the variance. Our findings should stimulate the search for genes responsible for these traits.

AB - Background and Purpose: Few family studies reported moderate genetic impact on the presence and scores of carotid plaques. However, the heritability of carotid plaque characteristics remains still unclear. Twin studies more reliably estimate the relative contribution of genes to these traits in contrast to family study design. Methods: One hundred ninety-two monozygotic and 83 dizygotic adult twin pairs (age 49 ± 15 years) from Italy, Hungary, and the United States underwent B-mode and color Doppler ultrasound of bilateral common, internal, and external carotid arteries. Results: Age-, sex-, and country-adjusted heritability was 78% for the presence of carotid plaque (95% CI, 55%-90%), 74% for plaque echogenicity (hypoechoic, hyperechoic, or mixed; 95% CI, 38%-87%), 69% for plaque size (area in mm2 in longitudinal plane; < or >50 percentile; 95% CI, 16%-86%), 74% for plaque sidedness (unilateral or bilateral; 95% CI, 25%-90%), 74% for plaque numerosity (95% CI, 26%-86%), 68% (95% CI, 40%-84%), and 66% (95% CI, 32%-90%) for the presence of plaque in carotid bulbs and proximal internal carotid arteries. No role of shared environmental factors was found. Unique environmental factors were responsible for the remaining variance (22%-34%). Controlling for relevant covariates did not change the results significantly. Conclusions: The heritability of ultrasound characteristics of carotid plaque is high. Unshared environmental effects account for a modest portion of the variance. Our findings should stimulate the search for genes responsible for these traits.

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UR - http://www.scopus.com/inward/citedby.url?scp=84870913570&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.112.666016

DO - 10.1161/STROKEAHA.112.666016

M3 - Article

VL - 43

SP - 3168

EP - 3172

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 12

ER -

ID: 3269405