Evidence for a strong genetic influence on carotid plaque characteristics: An International twin study

Adam Domonkos Tarnoki, Claudio Baracchini, David Laszlo Tarnoki, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Andrea Agnes Molnar, Giorgio Meneghetti, Maria Antonietta Stazi, Emanuela Medda, Rodolfo Cotichini, Lorenza Nisticò, Corrado Fagnani, Janos Osztovits, Gyorgy Jermendy, Istvan Preda, Robert Gabor Kiss, Julia Metneki, Tamas HorvathGiacomo Pucci, Pal Bata, Kinga Karlinger, Levente Littvay, Viktor Berczi, Zsolt Garami, Giuseppe Schillaci

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background and Purpose: Few family studies reported moderate genetic impact on the presence and scores of carotid plaques. However, the heritability of carotid plaque characteristics remains still unclear. Twin studies more reliably estimate the relative contribution of genes to these traits in contrast to family study design. Methods: One hundred ninety-two monozygotic and 83 dizygotic adult twin pairs (age 49 ± 15 years) from Italy, Hungary, and the United States underwent B-mode and color Doppler ultrasound of bilateral common, internal, and external carotid arteries. Results: Age-, sex-, and country-adjusted heritability was 78% for the presence of carotid plaque (95% CI, 55%-90%), 74% for plaque echogenicity (hypoechoic, hyperechoic, or mixed; 95% CI, 38%-87%), 69% for plaque size (area in mm2 in longitudinal plane; < or >50 percentile; 95% CI, 16%-86%), 74% for plaque sidedness (unilateral or bilateral; 95% CI, 25%-90%), 74% for plaque numerosity (95% CI, 26%-86%), 68% (95% CI, 40%-84%), and 66% (95% CI, 32%-90%) for the presence of plaque in carotid bulbs and proximal internal carotid arteries. No role of shared environmental factors was found. Unique environmental factors were responsible for the remaining variance (22%-34%). Controlling for relevant covariates did not change the results significantly. Conclusions: The heritability of ultrasound characteristics of carotid plaque is high. Unshared environmental effects account for a modest portion of the variance. Our findings should stimulate the search for genes responsible for these traits.

Original languageEnglish (US)
Pages (from-to)3168-3172
Number of pages5
JournalStroke
Volume43
Issue number12
DOIs
StatePublished - Dec 2012

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

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