Evidence for a fourth rat isoform of the plasma membrane calcium pump in the kidney

Juan M. Gonzalez, William Dalmeida, Joel Abramowitz, Wadi N. Suki

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

This study was conducted to identify plasma membrane Ca2+-transporting ATPases present in rat kidney. Characterization of the cDNAs of the plasma membrane Ca2+-ATPases revealed a family of proteins with regions of highly conserved amino acid sequence. To examine the extent of the diversity of rat renal plasma membrane Ca2+-ATPases, we used the polymerase chain reaction to detect additional gene products in rat kidney mRNA that shared these conserved regions. Sequences corresponding to three previously known rat plasma membrane Ca2+-ATPases were obtained. In addition, we found sequence corresponding to a new putative plasma membrane Ca2+-ATPase. Our results demonstrate that the rat kidney contains at least four different plasma membrane Ca2+-ATPases and the complexity of this multigene family is greater than previously thought.

Original languageEnglish (US)
Pages (from-to)387-393
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume184
Issue number1
DOIs
StatePublished - Apr 15 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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