Abstract
This study was conducted to identify plasma membrane Ca2+-transporting ATPases present in rat kidney. Characterization of the cDNAs of the plasma membrane Ca2+-ATPases revealed a family of proteins with regions of highly conserved amino acid sequence. To examine the extent of the diversity of rat renal plasma membrane Ca2+-ATPases, we used the polymerase chain reaction to detect additional gene products in rat kidney mRNA that shared these conserved regions. Sequences corresponding to three previously known rat plasma membrane Ca2+-ATPases were obtained. In addition, we found sequence corresponding to a new putative plasma membrane Ca2+-ATPase. Our results demonstrate that the rat kidney contains at least four different plasma membrane Ca2+-ATPases and the complexity of this multigene family is greater than previously thought.
Original language | English (US) |
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Pages (from-to) | 387-393 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 184 |
Issue number | 1 |
DOIs | |
State | Published - Apr 15 1992 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology