Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems

T. K. Pandita

doi:10.1016/0165-1218(86)90045-5

Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems

T. K. Pandita

Academic Institute

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

The insecticide Thimet 10-G was tested for mutagenic activity by 4 different genetic systems. It was unable to induce gene mutation in Salmonella, transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister-chromatid exchange (SCE) in human lymphocytes were evaluated. It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human lymphocytes a decrease in mitotic index and delay in cell cycle. The results indicate that the insecticide is not mutagenic in the 4 test systems used at present.

Original language	English (US)
Pages (from-to)	131-138
Number of pages	8
Journal	Mutation Research/Genetic Toxicology
Volume	171
Issue number	2-3
DOIs	https://doi.org/10.1016/0165-1218(86)90045-5
State	Published - 1986

ASJC Scopus subject areas

Toxicology
Genetics

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title = "Evaluation of Thimet 10-G for mutagenicity by 4 different genetic systems",

abstract = "The insecticide Thimet 10-G was tested for mutagenic activity by 4 different genetic systems. It was unable to induce gene mutation in Salmonella, transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister-chromatid exchange (SCE) in human lymphocytes were evaluated. It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human lymphocytes a decrease in mitotic index and delay in cell cycle. The results indicate that the insecticide is not mutagenic in the 4 test systems used at present.",

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AB - The insecticide Thimet 10-G was tested for mutagenic activity by 4 different genetic systems. It was unable to induce gene mutation in Salmonella, transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister-chromatid exchange (SCE) in human lymphocytes were evaluated. It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human lymphocytes a decrease in mitotic index and delay in cell cycle. The results indicate that the insecticide is not mutagenic in the 4 test systems used at present.

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