Evaluation of the renin angiotensin system in a congenic renin Dahl salt-sensitive rat

Nicholas R. DiPaola, Jr., J. P. Rapp, P. H. Brand, W. H. Beierwaltes, P. J. Metting, S. L. Britton

Research output: Contribution to journalArticlepeer-review

Abstract

When a >30 centiMorgans (cM) region of Chromosome 13 containing the renin gene from the Dahl/Rapp salt-resistant rat (SR/Jr) is introgressed into the Dahl/Rapp salt-sensitive rat (SS/Jr), the resulting congenic rat (SR-Ren) has a systolic blood pressure on a 2% salt diet that is 24 mmHg lower than its SS/Jr counterpart. We evaluated the role of the renin gene in the SR-Ren and SS/Jr strains by examining differences between strains in 1) expression of renin in plasma, kidney, and adrenal gland, 2) the blood pressure response to angiotensin converting enzyme inhibitor captopril and angiotensin II receptor blocker saralasin, and 3) pressure natriuresis. No differences were found in renin levels between strains. The blood pressure response to captopril and saralsin in conscious SS/Jr and SR/Ren rats was similar. Furthermore, renal function, evaluated by a pressure natriuresis index did not differ between strains. Our findings therefore fail to demonstrate a role for the rein gene in conferring lower blood pressure in the congenic rat and suggest that there is an unknown arterial pressure regulating locus in the 30 cM region of Chromosome 13.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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