Evaluation of the influence of fullerenol on aging and stress resistance using Caenorhabditis elegans

Wenshu Cong, Peng Wang, Ying Qu, Jinglong Tang, Ru Bai, Yuliang Zhao, C. Chen, Xiaolin Bi

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Fullerene derivatives have attracted extensive attention in biomedical fields and polyhydroxyl fullerene (fullerenol), a water-soluble fullerene derivative, is demonstrated as a powerful antioxidant. To further assess their anti-aging and anti-stress potential, we employed Caenorhabditis elegans (C.elegans) as a model organism to evaluate the effects of fullerenol on the growth, development, behavior and anti-stress ability invivo. The data show that fullerenol has no obviously toxic effect on nematodes and can delay C.elegans aging progress under normal condition. Further studies demonstrate that fullerenol attenuates endogenous levels of reactive oxygen species and provides protection to C.elegans under stress conditions by up-regulating stress-related genes in a DAF-16 depend manner and improving lifespan. In summary, our data suggest that fullerenol might be a safe and reasonable anti-aging candidate with great potential invivo.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalBiomaterials
Volume42
DOIs
StatePublished - Feb 1 2015

Keywords

  • Anti-aging
  • Caenorhabditis elegans
  • DAF-16
  • Fullerenol
  • Insulin/IGF-1 pathway
  • Lifespan

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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