Evaluation of the exoantigen test for identification of Histoplasma species and Coccidioides immitis cultures

A. F. Disalvo, A. S. Sekhon, G. A. Land, W. H. Fleming

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Recently it was demonstrated that certain fungal pathogens could be rapidly and accurately identified on the basis of their exoantigens. Mycelial-form cultures of the Histoplasma species consistently appear to produce either H or M antigens, or both, whereas cultures of Coccidioides immitis produce tube precipitinogen, heat-labile precipitinogen, or heat-labile F antigens. Three laboratories each evaluated 48 cultures by the exoantigen procedure for the identification of Histoplasma spp. and C. immitis. One hundred forty-four cultures were tested, and 143 (99.3%) were correctly identified as Histoplasma spp. or C. immitis, or neither. The simple and rapid exoantigen test appears to be a sensitive and specific method for identification of these fungi.

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalJournal of Clinical Microbiology
Volume11
Issue number3
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Microbiology (medical)

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