Evaluation of the classical methods for the diagnosis of type III hyperlipoproteinemia

J. R. Patsch, R. L. Jackson, Antonio Gotto

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Familial type III hyperlipoproteinemia is characterized by the presence of elevated plasma levels of very low density lipoproteins (VLDL) which contain an increased amount of cholesterol and by the presence of a significant amount of lipoproteins with an intermediate density between that of VLDL and low density lipoproteins (LDL); the intermediate density lipoproteins, designated IDL or Lp III, have a slower electrophoretic migration rate than VLDL, and are found in the ultracentrifugal top fraction as a contaminant. Classically, the diagnosis of type III is based on the demonstration of beta-migrating lipoproteins in the ultracentrifugal top fraction (density <1.006), thus "floating beta-lipoprotein". More recently, it has been proposed that an elevated VLDL-cholesterol to triglyceride ratio is diagnostic of the disorder. In the present report, we have compared the two methods for their diagnostic value and have concluded that the chemical index definition is the more reliable method for the diagnosis of type III hyperlipoproteinemia.

Original languageEnglish (US)
Pages (from-to)1025-1030
Number of pages6
JournalKlinische Wochenschrift
Volume55
Issue number21
DOIs
StatePublished - Nov 1 1977

Keywords

  • Dyslipoproteinemia
  • Hypercholesterolemia
  • Hypertriglyceridemia
  • Lipoprotein Electrophoresis
  • Ultracentrifugation

ASJC Scopus subject areas

  • Medicine(all)

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