Evaluation of efficacy and safety on steroid withdraw at the seventh day after liver transplantation

An bin Hu, Xiao shun He, Zhi peng Wu, Xiao feng Zhu, Y. Ma, Dong ping Wang, Guo dong Wang, Qiang Tai, Wei qiang Ju, Lin wei Wu, Jie fu Huang

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

OBJECTIVE: To evaluate efficacy and safety on steroid withdrawal at the seventh day after liver transplantation. METHODS: Seventy-six adult patients undergoing first cadaveric liver transplantation from October 2005 to October 2007 were randomly divided into 7 day (n = 40) and 3 month (n = 36) steroid withdrawal groups. All patients received FK506 3 mg and intravenous methylprednisolone 1000 mg during intra-operation and FK506 thereafter was adjusted to predefined 8 - 12 microg/L from day 1 to month 6. Patients in 7 day steroid withdrawal group received 500, 240, 200, 160, 80, 40 and 20 mg intravenous methylprednisolone tapered daily from postoperative day 1 to day 7. In 3 month steroid withdrawal group, patients received the same protocol as 7 day steroid withdrawal group for intravenous methylprednisolone tapered daily from postoperative day 1 to day 7 and thereafter received oral prednisone 48, 40, 32, 24, 16, 8, 4 mg tapered every 3 days and maintained 4 mg to the 3(rd) month. All patients were followed up for 6 months. The incidence of treated acute rejection and side effects were evaluated between two groups. RESULTS: A total of 69 cases were fully followed up, and 7 cases were discontinued including death (n = 2), server infection (n = 2), protocol violation (n = 2) and retransplantation (n = 1). There were no statistical difference between 2 groups concerning the incidence of acute rejection, hypertension, hyperlipemia and other adverse events (P > 0.05), but significant difference in incidence of diabetes (17.5% vs. 38.9%, P = 0.047). CONCLUSION: Steroid withdrawal strategy at day 7 is same safety and efficacy as steroid withdrawal at 3 month.

Original languageEnglish (US)
Pages (from-to)1126-1128
Number of pages3
JournalZhonghua wai ke za zhi [Chinese journal of surgery]
Volume46
Issue number15
StatePublished - Aug 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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