Evaluation of cell function upon nanovector internalization

Jonathan O. Martinez; Alessandro Parodi; Xuewu Liu; Mikhail G. Kolonin; Mauro Ferrari; Ennio Tasciotti

doi:10.1002/smll.201202001

Evaluation of cell function upon nanovector internalization

Jonathan O. Martinez, Alessandro Parodi, Xuewu Liu, Mikhail G. Kolonin, Mauro Ferrari, Ennio Tasciotti

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

Original language	English (US)
Pages (from-to)	1696-1702
Number of pages	7
Journal	Small
Volume	9
Issue number	9-10
DOIs	https://doi.org/10.1002/smll.201202001
State	Published - May 27 2013

Keywords

biocompatibility
cytotoxicity
mesoporous materials
nanomaterials
nanotechnology

ASJC Scopus subject areas

Biomaterials
Engineering (miscellaneous)
Biotechnology
General Medicine

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10.1002/smll.201202001

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title = "Evaluation of cell function upon nanovector internalization",

abstract = "In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.",

keywords = "biocompatibility, cytotoxicity, mesoporous materials, nanomaterials, nanotechnology",

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AU - Martinez, Jonathan O.

AU - Parodi, Alessandro

AU - Liu, Xuewu

AU - Kolonin, Mikhail G.

AU - Ferrari, Mauro

AU - Tasciotti, Ennio

PY - 2013/5/27

Y1 - 2013/5/27

N2 - In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

AB - In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

KW - biocompatibility

KW - cytotoxicity

KW - mesoporous materials

KW - nanomaterials

KW - nanotechnology

UR - https://www.scopus.com/pages/publications/84878055082

UR - https://www.scopus.com/inward/citedby.url?scp=84878055082&partnerID=8YFLogxK

U2 - 10.1002/smll.201202001

DO - 10.1002/smll.201202001

M3 - Review article

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AN - SCOPUS:84878055082

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ER -

Evaluation of cell function upon nanovector internalization

Abstract

Keywords

ASJC Scopus subject areas

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