Evaluation of acute renal failure with magnetic resonance imaging using gradient–echo and Gd–DTPA

Hirotsugu Munechika, Daniel C. Sullivan, Laurence W. Hedlund, Craig A. Beam, Henry D. Sostman, Robert J. Herfkens, Norbert J. Pelc

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 μg/kg/min) into the renal arteries of 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.

Original languageEnglish (US)
Pages (from-to)22-27
Number of pages6
JournalInvestigative Radiology
Volume26
Issue number1
DOIs
StatePublished - Jan 1991

Keywords

  • animal study
  • Gd-DTPA
  • kidney
  • kidney disease
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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