Evaluation of acute renal failure with magnetic resonance imaging using gradient–echo and Gd–DTPA

Hirotsugu Munechika; Daniel C. Sullivan; Laurence W. Hedlund; Craig A. Beam; Henry D. Sostman; Robert J. Herfkens; Norbert J. Pelc

doi:10.1097/00004424-199101000-00005

Evaluation of acute renal failure with magnetic resonance imaging using gradient–echo and Gd–DTPA

Hirotsugu Munechika, Daniel C. Sullivan, Laurence W. Hedlund, Craig A. Beam, Henry D. Sostman, Robert J. Herfkens, Norbert J. Pelc

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 μg/kg/min) into the renal arteries of 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.

Original language	English (US)
Pages (from-to)	22-27
Number of pages	6
Journal	Investigative Radiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1097/00004424-199101000-00005
State	Published - Jan 1991

Keywords

animal study
Gd-DTPA
kidney
kidney disease
MRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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10.1097/00004424-199101000-00005

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title = "Evaluation of acute renal failure with magnetic resonance imaging using gradient–echo and Gd–DTPA",

abstract = "Detection of acute renal failure (ARF) using fast-scan magnetic resonance imaging (MRI) with Gd-DTPA was studied in a dog model. ARF was produced in five dogs by infusion of norepinephrine (0.75 μg/kg/min) into the renal arteries of 40 minutes. MRI was performed 1 hour later and compared with baseline (pre-ARF) MRI. There was no significant difference in the ratios of signal intensity-vs.-time curves from 0 to 35 seconds after injection of Gd-DTPA. However, a difference between the outer and inner medulla was significant in the time period of 5 to 20 minutes after Gd-DTPA injection. These later signal intensity differences by fast-scan (gradient-echo) technique may be useful in the evaluation of ARF.",

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AU - Sostman, Henry D.

AU - Herfkens, Robert J.

AU - Pelc, Norbert J.

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Evaluation of acute renal failure with magnetic resonance imaging using gradient–echo and Gd–DTPA

Abstract

Keywords

ASJC Scopus subject areas

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