TY - JOUR
T1 - Evaluation of a new dynamic viscometer for measuring the viscosity of whole blood and plasma
AU - Chandler, W. L.
AU - Schmer, G.
PY - 1986
Y1 - 1986
N2 - We evaluated a new type of dynamic viscometer, the Sonoclot Coagulation Analyzer, for use in measuring the viscosity of whole-blood and plasma. Such information can be useful in monitoring patients with hyperviscosity syndromes, e.g., from multiple myeloma. A vibrating Teflon or plastic probe continuously measures synamic viscosity. The instrument can be calibrated to measure a range of viscosities from 0.69 to 23 cP (mN · s · m-2) or more. The coefficient of variation at 0.69 cP was 3-4% for measurements with Teflon probe, 7-9% with the plastic probe. Viscosity measured at 37°C for plasma and whole-blood samples from 20 normal patients was 1.22 (SD 0.05) cP and 3.63 (SD 0.52) cP, respectively. Dynamic viscosity measured in blood samples from a single source, with contrived hematocrits ranging from 0 to 89%, increased exponentially as a function of hematocrit, confirming previous studies. Overall, we found this instrument simple and quick to operate, producing accurate, precise viscosity measurements over at least a 40-fold range of viscosity.
AB - We evaluated a new type of dynamic viscometer, the Sonoclot Coagulation Analyzer, for use in measuring the viscosity of whole-blood and plasma. Such information can be useful in monitoring patients with hyperviscosity syndromes, e.g., from multiple myeloma. A vibrating Teflon or plastic probe continuously measures synamic viscosity. The instrument can be calibrated to measure a range of viscosities from 0.69 to 23 cP (mN · s · m-2) or more. The coefficient of variation at 0.69 cP was 3-4% for measurements with Teflon probe, 7-9% with the plastic probe. Viscosity measured at 37°C for plasma and whole-blood samples from 20 normal patients was 1.22 (SD 0.05) cP and 3.63 (SD 0.52) cP, respectively. Dynamic viscosity measured in blood samples from a single source, with contrived hematocrits ranging from 0 to 89%, increased exponentially as a function of hematocrit, confirming previous studies. Overall, we found this instrument simple and quick to operate, producing accurate, precise viscosity measurements over at least a 40-fold range of viscosity.
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U2 - 10.1093/clinchem/32.3.505
DO - 10.1093/clinchem/32.3.505
M3 - Article
C2 - 3948394
AN - SCOPUS:0022883918
VL - 32
SP - 505
EP - 507
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 3
ER -