Evaluation of a capillary measuring system for the characterisation of small tissue samples by impedance spectroscopy at higher frequencies

Impidjati, Fransisca Leonard, Hagen Thielecke

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

For the gentle and non-destructive characterisation of small tissue samples, non-invasive methods are required for biotechnological applications and medical diagnostics. One approach is the characterisation of small tissue samples by impedance spectroscopy using a measuring capillary. In this paper, the applicability of a capillary measuring system to record the impedance of a biological sample over a wide frequency range is evaluated using a suspension of human breast adenocarcinoma cells (MCF-7). Impedance spectra over a frequency range 1 Hz to 1.1 GHz were recorded. To describe the electrical properties of the cell suspensions, we use an equivalent circuit model containing advanced RC-elements. Changes of plasma membrane integrity of suspended cells were detectable.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages678-681
Number of pages4
ISBN (Print)0780387406, 9780780387409
DOIs
StatePublished - 2005
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: Sep 1 2005Sep 4 2005

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period9/1/059/4/05

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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