Evaluation and Management of Febrile, Well-appearing Young Infants

Eric A. Biondi, Carrie L. Byington

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The evaluation and management of well-appearing febrile infants less than 3 months of age has presented a decades-long clinical conundrum for providers. This article reviews the epidemiology of bacterial and viral infections in these infants. It discusses evidence-based diagnostic and treatment strategies, including appropriate use of testing, admission to the hospital, use of antibiotics, and hospital discharge. It also highlights the substantial variation in care for febrile infants and provides strategies to standardize practice.

Original languageEnglish (US)
Pages (from-to)575-585
Number of pages11
JournalInfectious Disease Clinics of North America
Issue number3
StatePublished - 2015


  • Fever
  • Infant
  • Management
  • Serious bacterial infection
  • Viral illness

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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