@inproceedings{1a6eabacc67a44e7998e040d259d0b6c,
title = "Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography",
abstract = "Fetal Alcohol Syndrome (FAS) refers to the broad spectrum of developmental and behavioral effects caused due to prenatal alcohol exposure (PAE). Wide range of abnormalities vary depending on the amount of alcohol consumed and the period of consumption during gestation. PAE during early stages of pregnancy is very common. However a large number of women continue to consume alcohol even during the second trimester, a critical period for fetal neurogenesis and angiogenesis. Optical coherence tomography (OCT) has shown to be extremely useful in embryonic imaging. Our previous work showed that OCT is capable of quantitative assessment of ventriculomegaly caused by maternal alcohol consumption. Although structural changes and changes in blood flow in the fetal brain after maternal alcohol consumption have been studied, acute vasculature changes are not well documented. Speckle variance OCT (SVOCT), is a functional extension of OCT that has been used to study vasculature development in embryos. We use SVOCT, to detect vasculature changes in the embryonic brain in utero, minutes after maternal alcohol consumption.",
author = "Raksha Raghunathan and Chen Wu and Manmohan Singh and Liu, \{Chih Hao\} and Miranda, \{Rajesh C.\} and Larin, \{Kirill V.\}",
note = "Publisher Copyright: {\textcopyright} 2017 SPIE.; 5th International Conference on Biophotonics, ICOB 2017 ; Conference date: 30-04-2017 Through 01-05-2017",
year = "2017",
doi = "10.1117/12.2277143",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Jurgen Popp and Wilson, \{Brian C.\} and Sampson, \{David D.\} and Matthews, \{Dennis L.\} and Halina Rubinsztein-Dunlop",
booktitle = "International Conference on Biophotonics V",
address = "United States",
}