ETIOLOGY AND CLINICAL CHARACTERISTICS OF MACULAR EDEMA IN PATIENTS WITH FAMILIAL EXUDATIVE VITREORETINOPATHY

Prethy Rao, Itsara Lertjirachai, Yoshihiro Yonekawa, Madeline Hasbrook, Benjamin J. Thomas, Edward H. Wood, Neesurg Mehta, Greta Mane, Kimberly A. Drenser, Michael T. Trese, Antonio Capone

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: To describe the etiology and clinical characteristics of macular edema (ME) in patients with familial exudative vitreoretinopathy. Methods: Observational, retrospective case series of 30 patients (34 eyes) with ME and familial exudative vitreoretinopathy who underwent spectral-domain optical coherence tomography imaging between 2009 and 2016. Baseline and follow-up optical coherence tomographies were correlated with color fundus photography and fluorescein angiography. Results: The average age was 20.6 years (6.6–68.7). Eighteen eyes exhibited cystoid ME (52.9%), 14 noncystoid ME (41.2%), and 2 eyes (5.9%) with both. Macular edema was foveal in 52.9% (n = 18). Eighteen of 24 eyes (64.3%) with an available fluorescein angiography showed leakage from ME. The most common structural feature was posterior hyaloidal organization/ contraction (n = 15). Sixteen eyes were treated with topical or intravitreal steroids (n = 6), intravitreal anti–vascular endothelial growth factor (n = 3), or pars plana vitrectomy with membrane stripping (n = 7). There was no difference between mean preoperative and postoperative LogMAR visual acuity (0.63 [20/85] vs. 0.87 [20/148], P = 0.35) after vitrectomy despite a statistical improvement in the mean central foveal thickness (596 mm3 vs. 303 mm3, P = 0.04). Conclusion: Macular edema in familial exudative vitreoretinopathy occurs most commonly because of traction. Vitrectomy is effective for relieving tractional forces with anatomical improvement.

Original languageEnglish (US)
Pages (from-to)1367-1373
Number of pages7
JournalRetina
Volume40
Issue number7
DOIs
StatePublished - Jul 1 2020

Keywords

  • Cystoid macular edema
  • FEVR
  • Macular edema
  • Noncystoid macular edema
  • SD-OCT

ASJC Scopus subject areas

  • Ophthalmology

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