Estrogen signaling via estrogen receptor β

Chunyan Zhao, Karin Dahlman-Wright, Jan Åke Gustafsson

    Research output: Contribution to journalShort surveypeer-review

    104 Scopus citations

    Abstract

    Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context. This minireview will provide an overview of the most recent advances in the identification of ERβ-regulated target gene networks and ERβ DNA-binding sites. We also highlight the recent work establishing new roles of ERβ signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon.

    Original languageEnglish (US)
    Pages (from-to)39575-39579
    Number of pages5
    JournalJournal of Biological Chemistry
    Volume285
    Issue number51
    DOIs
    StatePublished - Dec 17 2010

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

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