Estrogen signaling and unfolded protein response in breast cancer

Gayani Rajapaksa, Christoforos Thomas, Jan-Ake Gustafsson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Activation of the unfolded protein response (UPR) confers resistance to anti-estrogens and chemotherapeutics in estrogen receptor α (ERα)-positive and triple-negative breast cancers. Among the regulators of the UPR in breast cancer is estrogen signaling. Estrogen regulates major components of the UPR and ER expression is associated with the sensitivity of tumor cells to UPR-regulated apoptosis. Recent studies have confirmed the crosstalk between the ERs and UPR and suggest novel therapeutic strategies that combine targeting of both signaling pathways. These remedies may be more effective in repressing oncogenic adaptive mechanisms and benefit patients with resistant disease.

Original languageEnglish (US)
JournalJournal of Steroid Biochemistry and Molecular Biology
StateAccepted/In press - Jan 18 2016


  • Breast cancer
  • Endocrine resistance
  • Estrogen
  • Nuclear receptors
  • Unfolded protein response

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Molecular Medicine


Dive into the research topics of 'Estrogen signaling and unfolded protein response in breast cancer'. Together they form a unique fingerprint.

Cite this