TY - JOUR
T1 - Estrogen receptors in colorectal cancer
T2 - Goalkeepers, strikers, or bystanders?
AU - Hartman, Johan
AU - Gustafsson, Jan Åke
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/8
Y1 - 2010/8
N2 - This perspective on Jin et al. (beginning on page 910 in this issue of the journal) discusses the importance of estrogen signaling in colorectal carcinogenesis, with a focus on estrogen receptor β (ERβ), which is the predominant ER in the colorectal epithelium. The importance of ERβ in breast cancer is well described in the literature, and recent studies reveal that ERβ functions similarly in colorectal cancer. The implications of this pathway include new possibilities to treat or prevent colorectal cancer with targeted endocrine drugs and the potential of ERβ as a novel diagnostic tool.
AB - This perspective on Jin et al. (beginning on page 910 in this issue of the journal) discusses the importance of estrogen signaling in colorectal carcinogenesis, with a focus on estrogen receptor β (ERβ), which is the predominant ER in the colorectal epithelium. The importance of ERβ in breast cancer is well described in the literature, and recent studies reveal that ERβ functions similarly in colorectal cancer. The implications of this pathway include new possibilities to treat or prevent colorectal cancer with targeted endocrine drugs and the potential of ERβ as a novel diagnostic tool.
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U2 - 10.1158/1940-6207.CAPR-10-0132
DO - 10.1158/1940-6207.CAPR-10-0132
M3 - Review article
C2 - 20663982
AN - SCOPUS:77955433881
SN - 1940-6207
VL - 3
SP - 897
EP - 899
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 8
ER -