Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

Olle Vidal; Marie K. Lindberg; Karin Hollberg; David J. Baylink; Göran Andersson; Dennis B. Lubahn; Subburaman Mohan; Jan Åke Gustafsson; Claes Ohlsson

doi:10.1073/pnas.97.10.5474

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

Olle Vidal, Marie K. Lindberg, Karin Hollberg, David J. Baylink, Göran Andersson, Dennis B. Lubahn, Subburaman Mohan, Jan Åke Gustafsson, Claes Ohlsson

Research Institute

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Abstract

Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.

Original language	English (US)
Pages (from-to)	5474-5479
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	97
Issue number	10
DOIs	https://doi.org/10.1073/pnas.97.10.5474
State	Published - May 9 2000

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Vidal, O., Lindberg, M. K., Hollberg, K., Baylink, D. J., Andersson, G., Lubahn, D. B., Mohan, S., Gustafsson, J. Å., & Ohlsson, C. (2000). Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice. Proceedings of the National Academy of Sciences of the United States of America, 97(10), 5474-5479. https://doi.org/10.1073/pnas.97.10.5474

Vidal, O, Lindberg, MK, Hollberg, K, Baylink, DJ, Andersson, G, Lubahn, DB, Mohan, S, Gustafsson, JÅ & Ohlsson, C 2000, 'Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 10, pp. 5474-5479. https://doi.org/10.1073/pnas.97.10.5474

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AU - Vidal, Olle

AU - Lindberg, Marie K.

AU - Hollberg, Karin

AU - Baylink, David J.

AU - Andersson, Göran

AU - Lubahn, Dennis B.

AU - Mohan, Subburaman

AU - Gustafsson, Jan Åke

AU - Ohlsson, Claes

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AB - Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.

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Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

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