Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

Olle Vidal, Marie K. Lindberg, Karin Hollberg, David J. Baylink, Göran Andersson, Dennis B. Lubahn, Subburaman Mohan, Jan Åke Gustafsson, Claes Ohlsson

Research output: Contribution to journalArticle

306 Scopus citations

Abstract

Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.

Original languageEnglish (US)
Pages (from-to)5474-5479
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number10
DOIs
StatePublished - May 9 2000

ASJC Scopus subject areas

  • General

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