Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

Olle Vidal, Marie K. Lindberg, Karin Hollberg, David J. Baylink, Göran Andersson, Dennis B. Lubahn, Subburaman Mohan, Jan Åke Gustafsson, Claes Ohlsson

    Research output: Contribution to journalArticlepeer-review

    347 Scopus citations

    Abstract

    Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERα-knockout (ERKO), ERβ-knockout (BERKO), and double ERα/β-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERα, but not ERβ, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.

    Original languageEnglish (US)
    Pages (from-to)5474-5479
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume97
    Issue number10
    DOIs
    StatePublished - May 9 2000

    ASJC Scopus subject areas

    • General

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