Estrogen receptor specificity for the effects of estrogen in ovariectomized mice

M. K. Lindberg, Z. Weihua, N. Andersson, S. Movérare, H. Gao, O. Vidal, M. Erlandsson, S. Windahl, G. Andersson, D. B. Lubahn, H. Carlsten, K. Dahlman-Wright, J. Å Gustafsson, C. Ohlsson

Research output: Contribution to journalArticle

139 Scopus citations

Abstract

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), α and β. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 μg/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERα activity or represent an ERα/ERβ-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERα mediated.

Original languageEnglish (US)
Pages (from-to)167-178
Number of pages12
JournalJournal of Endocrinology
Volume174
Issue number2
DOIs
StatePublished - Aug 2002

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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