Estrogen receptor concentrations in 269 cases of histologically classified human breast cancer

Claes Silfverswärd, Jan‐Åke Gustafsson, Sven A. Gustafsson, Solveig Humla, Bo Nordenskjöld, Arne Wallgren, Örjan Wrange

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

This report provides a histological review of 264 female primary breast estrogen analyzed for estrofen receptor protein (ER). The authors also describe 5 cases of male breast cancer all of which bound estradiol specifically. Generally the ER concentrations were lower in the tumors of premenopausal women than in those of postmenopausal women. Three types of cancer specific morphological features were shown to have ER concentrations that differed significantly from the other types of cancer. Medullary and comedo carcinoma had very low and papillary carcinoma very high levels of ER concentration was found in unspecified ductal carcinoma, colloid carcinoma, nor in lobular carcinoma. A positive correlation was demonstrated between ER content and degree of differentiation in ductal carcinoma. Cancer with lymphoid infiltration generally showed low ER levels.

Original languageEnglish (US)
Pages (from-to)2001-2005
Number of pages5
JournalCancer
Volume45
Issue number8
DOIs
StatePublished - Apr 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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