This report provides a histological review of 264 female primary breast estrogen analyzed for estrofen receptor protein (ER). The authors also describe 5 cases of male breast cancer all of which bound estradiol specifically. Generally the ER concentrations were lower in the tumors of premenopausal women than in those of postmenopausal women. Three types of cancer specific morphological features were shown to have ER concentrations that differed significantly from the other types of cancer. Medullary and comedo carcinoma had very low and papillary carcinoma very high levels of ER concentration was found in unspecified ductal carcinoma, colloid carcinoma, nor in lobular carcinoma. A positive correlation was demonstrated between ER content and degree of differentiation in ductal carcinoma. Cancer with lymphoid infiltration generally showed low ER levels.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Apr 15 1980|
ASJC Scopus subject areas
- Cancer Research