Estrogen receptor beta in health and disease

Otabek Imamov, Gil Jin Shim, Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


Estrogens, acting through its two receptors, ESR1 (hereafter designated ER alpha) and ESR2 (hereafter designated ER beta), have diverse physiological effects in the reproductive system, bone, cardiovascular system, hematopoiesis, and central and peripheral nervous systems. Mice with inactivated ER alpha, ER beta, or both show a number of interesting phenotypes, including incompletely differentiated epithelium in tissues under steroidal control (prostate, ovary, mammary, and salivary glands) and defective ovulation reminiscent of polycystic ovarian syndrome in humans (in ER beta-/- mice), and obesity, insulin resistance, and complete infertility (both in male and female ER alpha -/- mice). Estrogen agonists and antagonists are frequently prescribed drugs with indications that include postmenopausal syndrome (agonists) and breast cancer (antagonists). Because the two estrogen receptors (ERs) have different physiological functions and have ligand binding pockets that differ enough to be selective in their ligand binding, opportunities now exist for development of novel ER subtype-specific selective-ER modulators.

Original languageEnglish (US)
Pages (from-to)866-871
Number of pages6
JournalBiology of Reproduction
Issue number5
StatePublished - Nov 2005


  • Estradiol
  • Estradiol receptor
  • Immunology
  • Neurotransmitters
  • Prostate

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Embryology


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