Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer

Paula Maguire, Sara Margolin, Johanna Skoglund, Xiao Feng Sun, Jan Åke Gustafsson, Anne Lise Børresen-Dale, Annika Lindblom

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Estrogen is involved in both normal mammary development and in breast carcinogenesis. A family history of disease and exposure to estrogen are major risk factors for developing breast cancer. Estrogen exerts its biological effects through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2). Genetic variation in genes involved in estrogen biosynthesis, metabolism and signal transduction have been suggested to play a role in breast cancer risk. We therefore tested the hypothesis that common genetic variants of the ESR2 gene may be associated with increased risk for breast cancer and this risk may vary between breast cancer groups. We investigated three common ESR2 polymorphisms, rs1256049 (G1082A), rs4986938 (G1730A) and rs928554 (Cx+56 A→G) for association to breast cancer risk. A total of 723 breast cancer cases and 480 controls were included in the study. Of the breast cancer cases, 323 were sporadic and 400 were familial, the familial cases were further divided into familial high-risk and familial low-risk breast cancer cases. We found no overall statistically significant association for any of the single polymorphisms studied. Haplotype analysis suggested one haplotype associated with increased risk in sporadic breast cancer patients (OR = 3.0, p = 0.03). Further analysis is needed to elucidate the role of estrogen receptor beta in breast cancer susceptibility.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalBreast Cancer Research and Treatment
Volume94
Issue number2
DOIs
StatePublished - Nov 2005

Keywords

  • Association
  • Breast cancer
  • ESR2
  • Estrogen receptor beta
  • Familial breast cancer
  • Haplotype
  • Polymorphism
  • Sporadic breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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