Estrogen receptor alpha and beta in health and disease

Min Jia, Karin Dahlman-Wright, Jan Åke Gustafsson

Research output: Contribution to journalReview articlepeer-review

205 Scopus citations

Abstract

Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors that are involved in the regulation of many complex physiological processes in humans. Abnormal ER signaling leads to development of a variety of diseases, such as cancer, metabolic and cardiovascular disease, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update on ERα and ERβ in health and disease with focus on their role in cancer and metabolic disease and in the context of recent years' success in providing genome wide data on ER function. Furthermore, potential clinical applications and challenges are also discussed.

Original languageEnglish (US)
Pages (from-to)557-568
Number of pages12
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Volume29
Issue number4
DOIs
StatePublished - Aug 1 2015

Keywords

  • cancer
  • estrogen receptors
  • metabolic disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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