Estrogen receptor β regulates sexually dimorphic neural responses to estradiol

Jennifer L. Temple, Heather N. Fugger, Xia Li, Savera J. Shetty, Jan Åke Gustafsson, Emilie F. Rissman

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Estrogen receptors (ERs) mediate many sexual dimorphisms in the neuroendocrine system and in behavior. We examined the consequences of the loss of functional estrogen receptor β (ERβ) on two sexually differentiated neural responses to estrogen. In wild type (WT) male mice, but not in females, estradiol (E2) treatment decreased estrogen receptor α immunoreactive (ERα-ir) cell numbers in the arcuate nucleus (ARC), the preoptic area (POA), and the ventromedial nucleus (VMN). These sex differences were reversed in ERβ knockout (ERβKO) mice. Castrated ERβKOs did not show any change in ERα-ir cell number after E2 treatment. Yet, E2 decreased ERα-ir cell number in ovariectomized ERβKOs. Estradiol treatment increased progesterone receptor immunoreactive (PR-ir) cell number in WT female VMN and POA, but no change was noted in brains of WT castrates. In ERβKO mice the opposite relationship was found, E2 treatment increased PR-ir cell number in male, but not in female, brains. Our results show that ERβ influences several sexually dimorphic neural responses to estrogen. Moreover the data clearly show that ERβ can modulate neural expression of ERα.

Original languageEnglish (US)
Pages (from-to)510-513
Number of pages4
Issue number1
StatePublished - 2001

ASJC Scopus subject areas

  • Endocrinology


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