Estrogen receptor β - A new dimension in estrogen mechanism of action

Jan-Ake Gustafsson

Research output: Contribution to journalReview articlepeer-review

394 Scopus citations


Cloning of the novel estrogen receptor β (ERβ) has led to a paradigm shift in our understanding of estrogen action. The concept of a second estrogen receptor with somewhat different ligand binding specificity than the previously known receptor (ERα) opens up the possibility for development of novel estrogenic drugs that might distinguish between the two receptors. This could be of importance in treatment of various diseases, as the two receptors seem to be differentially expressed in several tissues. ERβ appears to be very important in the central nervous system, bone, lung, urogenital tract, cardiovascular system, ovary, testis, kidney and colon. The physiological function of ERβ is under intense study but certain results indicate that ERα and ERβ have different or even opposite biological actions.

Original languageEnglish (US)
Pages (from-to)379-383
Number of pages5
JournalJournal of Endocrinology
Issue number3
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'Estrogen receptor β - A new dimension in estrogen mechanism of action'. Together they form a unique fingerprint.

Cite this