Abstract
A human carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver tumors in female rats. In this study, we examined the effects of estrogen on an arylhydrocarbon receptor (AhR)-responsible protein, CYP1A1 expression induced by TCDD in female rat livers. The induction of CYP1A1 by a dose of 300 ng TCDD/kg and its resultant enzymatic activity were significantly enhanced by 5 microg 17beta-estradiol/kg body weight treatment to both intact and ovariectomized rats. Immunoblot analysis showed a increase in nuclear AhR due to estrogen, TCDD or both, suggesting that estrogen is involved in the activation of CYP1A1 gene after the formation of AhR-TCDD complex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-147 |
| Number of pages | 7 |
| Journal | International Journal of Oncology |
| Volume | 16 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2000 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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