TY - JOUR
T1 - Estrogen enhances induction of cytochrome P-4501A1 by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in liver of female Long-Evans rats.
AU - Sarkar, S.
AU - Jana, N. R.
AU - Yonemoto, J.
AU - Tohyama, C.
AU - Sone, H.
PY - 2000/1
Y1 - 2000/1
N2 - A human carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver tumors in female rats. In this study, we examined the effects of estrogen on an arylhydrocarbon receptor (AhR)-responsible protein, CYP1A1 expression induced by TCDD in female rat livers. The induction of CYP1A1 by a dose of 300 ng TCDD/kg and its resultant enzymatic activity were significantly enhanced by 5 microg 17beta-estradiol/kg body weight treatment to both intact and ovariectomized rats. Immunoblot analysis showed a increase in nuclear AhR due to estrogen, TCDD or both, suggesting that estrogen is involved in the activation of CYP1A1 gene after the formation of AhR-TCDD complex.
AB - A human carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces liver tumors in female rats. In this study, we examined the effects of estrogen on an arylhydrocarbon receptor (AhR)-responsible protein, CYP1A1 expression induced by TCDD in female rat livers. The induction of CYP1A1 by a dose of 300 ng TCDD/kg and its resultant enzymatic activity were significantly enhanced by 5 microg 17beta-estradiol/kg body weight treatment to both intact and ovariectomized rats. Immunoblot analysis showed a increase in nuclear AhR due to estrogen, TCDD or both, suggesting that estrogen is involved in the activation of CYP1A1 gene after the formation of AhR-TCDD complex.
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U2 - 10.3892/ijo.16.1.141
DO - 10.3892/ijo.16.1.141
M3 - Article
C2 - 10601559
AN - SCOPUS:0033629022
VL - 16
SP - 141
EP - 147
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 1
ER -