Estrogen and progesterone receptors in ovarian epithelial tumors

Peter R. Lindgren, Stefan Cajander, Torbjörn Bäckström, Jan Åke Gustafsson, Sari Mäkelä, Jan I. Olofsson

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Epidemiological studies have indicated a relationship between ovarian cancer and gonadal steroid hormones. In the present study immunohistochemical localization in combination with morphometry were used to characterize changes in the pattern of expression for estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and progesterone receptor (PR), in epithelial cells of normal ovaries, and in benign, borderline and malignant ovarian tumors of different types (n=53). Positive correlations with immunoreactivity of the cell proliferation-marker, Ki67, and the apoptosis-related marker of genetic instability, p53, between the different tumor types were also found. A simultaneous expression of ERα, ERβ and PR in epithelial cells of all histopathological tumor types was noted, with the notable exception of all mucinous tumors who remained ERβ-positive, but ERα- and PR-negative. Epithelial cells in ovarian cancer tissue showed significantly lower mean immunoreactivity of ERβ and PR, but not ERα, than in normal ovarian tissue. These novel findings may provide a rationale for the development of new diagnostic and possibly therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalMolecular and cellular endocrinology
Volume221
Issue number1-2
DOIs
StatePublished - Jun 30 2004

Keywords

  • Immunohistochemistry
  • Ki67
  • Ovarian cancer
  • Ovarian tumors
  • p53
  • Steroid hormone receptors

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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