Estrogen and Progesterone Receptors in Bronchogenic Carcinoma

Philip T. Cagle, Dina R. Mody, Mary R. Schwartz

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

Although the lung is not usually considered a major target organ of sex hormones, epidemiologieal observations, studies of pulmonary neoplasms in laboratory animals, and investigations of carcinomas derived from other "nontarget" organs suggest that sex hormones may have a role in the pathogenesis of bronchogenic carcinoma. To confirm that estrogen (ER) and progesterone receptors are present in human lung cancers, 19 resected lung cancers were examined for receptors using a prelabeled sucrose gradient method. Three squamous cell carcinomas were positive for ER (>6.9 fmol/mg cytosol protein). Three squamous cell carcinomas, two adenocarcinomas, and one small cell carcinoma were positive for progesterone receptors (>6.9 fmol/mg cytosol protein). One tumor, a squamous cell carcinoma arising in a woman who smoked, had an ER level of 301 fmol/mg, a highly positive level even for breast cancers. These observations may provide a basis for adjuvant hormonal therapy in selected lung cancer patients.

Original languageEnglish (US)
Pages (from-to)6632-6635
Number of pages4
JournalCancer research
Volume50
Issue number20
StatePublished - Oct 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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