Estimation of the β+ dose to the embryo resulting from 18F-FDG administration during early pregnancy

Paolo Zanotti-Fregonara, Christophe Champion, Régine Trébossen, Renaud Maroy, Jean Yves Devaux, Elif Hindié

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Although 18F-FDG examinations are widely used, data are lacking on the dose to human embryo tissues in cases of exposure in early pregnancy. Although the photon component can easily be estimated from available data on the pharmacokinetics of 18F-FDG in female organs and from phantom measurements (considering the uterus as the target organ), the intensity of embryo tissue uptake, which is essential for deriving the β+ dose, is not known. We report the case of a patient who underwent 18F-FDG PET/CT for tumor surveillance and who was later found to have been pregnant at the time of the examination (embryo age, 8 wk). Methods: The patient received 320 MBq of 18F-FDG. Imaging started with an unenhanced CT scan 1 h after the injection, followed by PET acquisition. PET images were used to compute the total number of β+ emissions in embryo tissues per unit of injected activity, from standardized uptake value (SUV) measurements corrected for partial-volume effects. A Monte Carlo track structure code was then used to derive the β+ self-dose and the β+ cross-dose from amniotic fluid. The photon and CT doses were added to obtain the final dose received by the embryo. Results: The mean SUV in embryo tissues was 2.7, after correction for the partial-volume effect. The mean corrected SUV of amniotic fluid was 1.1. Monte Carlo simulation showed that the β+ dose to the embryo (self-dose plus cross-dose from amniotic fluid) was 1.8E-2 mGy per MBq of injected 18F-FDG. Based on MIRD data for the photon dose to the uterus, the estimated photon dose to the embryo was 1.5E-2 mGy/ MBq. Thus, the specific 18F-FDG dose to the embryo was 3.3E22 mGy/MBq (10.6 mGy in this patient). The CT scan added a further 8.3 mGy. Conclusion: The dose to the embryo is 3.3E-2 mGy/MBq of 18F-FDG. The β+ dose contributes 55% of the total dose. This value is higher than previous estimates in late nonhuman-primate pregnancies. COPYRIGHT

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalJournal of Nuclear Medicine
Volume49
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Embryo dosimetry
  • F-FDG
  • Monte carlo simulation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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