TY - JOUR
T1 - Estimation of Mechanical and Transport Parameters in Cancers Using Short Time Poroelastography
AU - Majumder, Sharmin
AU - Islam, Md Tauhidul
AU - Righetti, Raffaella
N1 - Publisher Copyright:
© 2013 IEEE.
PY - 2022
Y1 - 2022
N2 - Mechanical and transport properties of cancers such as Young's modulus (YM), Poisson's ratio (PR), and vascular permeability (VP) have great clinical importance in cancer diagnosis, prognosis, and treatment. However, non-invasive estimation of these parameters in vivo is challenged by many practical factors. Elasticity imaging methods, such as 'poroelastography', require prolonged data acquisition, which can limit their clinical applicability. In this paper, we investigate a new method to perform poroelastography experiments, which results in shorter temporal acquisition windows. This method is referred to as 'short-time poroelastography' (STPE). Finite element (FE) and ultrasound simulations demonstrate that, using STPE, it is possible to accurately estimate YM, PR (within 10% error) using windows of observation (WoOs) of length as short as 1 underlying strain Time Constant (TC). The error was found to be almost negligible (< 3%) when using WoOs longer than 2 strain TCs. In the case of VP estimation, WoOs of at least 2 strain TCs are required to obtain an error < 8% (in simulations). The stricter requirement for the estimation of VP with respect to YM and PR is due its reliance on the transient strain behavior while YM and PR depend on the steady state strain values only. In vivo experimental data are used as a proof-of-principle of the potential applicability of the proposed methodology in vivo. The use of STPE may provide a means to efficiently perform poroelastography experiments without compromising the accuracy of the estimated tissue properties.
AB - Mechanical and transport properties of cancers such as Young's modulus (YM), Poisson's ratio (PR), and vascular permeability (VP) have great clinical importance in cancer diagnosis, prognosis, and treatment. However, non-invasive estimation of these parameters in vivo is challenged by many practical factors. Elasticity imaging methods, such as 'poroelastography', require prolonged data acquisition, which can limit their clinical applicability. In this paper, we investigate a new method to perform poroelastography experiments, which results in shorter temporal acquisition windows. This method is referred to as 'short-time poroelastography' (STPE). Finite element (FE) and ultrasound simulations demonstrate that, using STPE, it is possible to accurately estimate YM, PR (within 10% error) using windows of observation (WoOs) of length as short as 1 underlying strain Time Constant (TC). The error was found to be almost negligible (< 3%) when using WoOs longer than 2 strain TCs. In the case of VP estimation, WoOs of at least 2 strain TCs are required to obtain an error < 8% (in simulations). The stricter requirement for the estimation of VP with respect to YM and PR is due its reliance on the transient strain behavior while YM and PR depend on the steady state strain values only. In vivo experimental data are used as a proof-of-principle of the potential applicability of the proposed methodology in vivo. The use of STPE may provide a means to efficiently perform poroelastography experiments without compromising the accuracy of the estimated tissue properties.
KW - Cancer imaging
KW - Poroelastography
KW - Strain time constant
KW - Vascular permeability
KW - Young's modulus and Poissona's ratio
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U2 - 10.1109/JTEHM.2022.3198316
DO - 10.1109/JTEHM.2022.3198316
M3 - Article
C2 - 36147877
AN - SCOPUS:85136678225
VL - 10
JO - IEEE Journal of Translational Engineering in Health and Medicine
JF - IEEE Journal of Translational Engineering in Health and Medicine
SN - 2168-2372
M1 - 1900411
ER -