Esterification‐coupled extraction of organic acids: Partition enhancement and underlying reaction and distribution equilibria

M. R. Aires‐Barros; J. M.S. Cabral; R. C. Willson; J. ‐F P. Hamel; C. L. Cooney

doi:10.1002/bit.260340705

Esterification‐coupled extraction of organic acids: Partition enhancement and underlying reaction and distribution equilibria

M. R. Aires‐Barros, J. M.S. Cabral, R. C. Willson, J. ‐F P. Hamel, C. L. Cooney

Houston Methodist

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A novel means of extracting carboxylic acids from aqueous solutions is described which involves the use of a lipolytic enzyme to convert the acid to a more hydrophobic ester. A water-immiscible long-chain alcohol serves both as a reactant in esterifying the acid, and as a solvent for extraction of the ester. The net result is a substantial (4-to 15-fold) increase in the apparent distribution coefficient of the acid; 80%-95% of the extracted acid is in the esterified form. The method is applicable to a variety of alcohols and acids.

Original language	English (US)
Pages (from-to)	909-915
Number of pages	7
Journal	Biotechnology and Bioengineering
Volume	34
Issue number	7
DOIs	https://doi.org/10.1002/bit.260340705
State	Published - Oct 5 1989

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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abstract = "A novel means of extracting carboxylic acids from aqueous solutions is described which involves the use of a lipolytic enzyme to convert the acid to a more hydrophobic ester. A water-immiscible long-chain alcohol serves both as a reactant in esterifying the acid, and as a solvent for extraction of the ester. The net result is a substantial (4-to 15-fold) increase in the apparent distribution coefficient of the acid; 80%-95% of the extracted acid is in the esterified form. The method is applicable to a variety of alcohols and acids.",

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AU - Willson, R. C.

AU - Hamel, J. ‐F P.

AU - Cooney, C. L.

PY - 1989/10/5

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Esterification‐coupled extraction of organic acids: Partition enhancement and underlying reaction and distribution equilibria

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