Esterification‐coupled extraction of organic acids: Partition enhancement and underlying reaction and distribution equilibria

M. R. Aires‐Barros, J. M.S. Cabral, Richard C. Willson, J. ‐F P. Hamel, C. L. Cooney

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A novel means of extracting carboxylic acids from aqueous solutions is described which involves the use of a lipolytic enzyme to convert the acid to a more hydrophobic ester. A water-immiscible long-chain alcohol serves both as a reactant in esterifying the acid, and as a solvent for extraction of the ester. The net result is a substantial (4-to 15-fold) increase in the apparent distribution coefficient of the acid; 80%-95% of the extracted acid is in the esterified form. The method is applicable to a variety of alcohols and acids.

Original languageEnglish (US)
Pages (from-to)909-915
Number of pages7
JournalBiotechnology and Bioengineering
Volume34
Issue number7
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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